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- Title
The Decline of Pertussis-Specific Antibodies After Tetanus, Diphtheria, and Acellular Pertussis Immunization in Late Pregnancy.
- Authors
Raya, Bahaa Abu; Srugo, Isaac; Kessel, Aharon; Peterman, Michael; Vaknin, Avraham; Bamberger, Ellen; Abu Raya, Bahaa
- Abstract
We prospectively measured pertussis-specific antibodies 9-15 months after delivery in women immunized with tetanus, diphtheria, and acellular pertussis (Tdap) after the 20th week of their recent pregnancy. The Tdap-immunized women (n = 38) exhibited a decline in geometric mean concentrations between their peripartum and follow-up levels for immunoglobulin G to pertussis toxin (21.48 [95% confidence interval, 12.51-36.89] vs 11.72 [7.09-19.37] IU/mL];); filamentous hemagglutinin (185.95 [157.93-218.94] vs 140.33 IU/mL [113.46-173.57] IU/mL); and pertactin (171.52 [120.73-243.67] vs 83.74 [60.58-115.75] IU/mL) (all P < .001). For women immunized with Tdap during late pregnancy, pertussis-specific immunoglobulin G levels decreased significantly 9-15 months after delivery.
- Subjects
WHOOPING cough; IMMUNOGLOBULINS; IMMUNIZATION; PREGNANT women; IMMUNOGLOBULIN G; PERTUSSIS toxin; HEMAGGLUTININ; FOLLOW-up studies (Medicine); BACTERIAL antigens; BACTERIAL toxins; DPT vaccines; LONGITUDINAL method; MEMBRANE proteins; TIME; BACTERIAL antibodies
- Publication
Journal of Infectious Diseases, 2015, Vol 212, Issue 12, p1869
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv324