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- Title
A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.
- Authors
Gilbert, Akankwasa; Jianhua Liu; Guixue Cheng; Changjuan An; Kabuye Deo; Gorret, Abalinda Mary; Xiaosong Qin
- Abstract
Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies have demystified urine ACE2 in many ways and suggested the roles it could play in the management of diabetic nephropathy. In all studies the expression of urinary ACE2 was determined by enzyme activity assay and/with the quantification of ACE2 protein and mRNA by methods whose reliability are yet to be evaluated. This review summarizes recent findings on expression of urinary ACE2, examines its relationship with clinical parameters and highlights possible applications in management of diabetic nephropathy.
- Subjects
ANGIOTENSIN converting enzyme; DIABETIC nephropathies; MESSENGER RNA; KIDNEY diseases; ENZYME activation
- Publication
Biochemia Medica, 2019, Vol 29, Issue 1, p1
- ISSN
1330-0962
- Publication type
Article
- DOI
10.11613/BM.2019.010501