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- Title
Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis
- Authors
Koekemoer, Andrea L.; Chong, Nelson W.; Goodall, Alison H.; Samani, Nilesh J.
- Abstract
Abstract: Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localized with actin in H9c2 cells and altered expression of genes of the myocardin-related transcription factor (MRTF)/serum response factor (SRF) transcriptional pathways and in addition the apoptosis repressor with caspase recruitment domain (Nol3) gene. The size of cells over-expressing MS1 was significantly increased by 55% and over-expression of MS1 dramatically inhibited staurosporine-induced apoptosis by 89%. These findings suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis.
- Subjects
MUSCLE cells; MUSCLE contraction; HYPERTROPHY; APOPTOSIS; CARRIER proteins; PHYSIOLOGIC strain; CELLULAR control mechanisms; LEFT heart ventricle
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2964
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.08.011