We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Homeothermy in neonatal chicks exposed to low environmental temperature with or without intracerebroventricular administration of corticotropin-releasing factor
- Authors
Mujahid, Ahmad; Furuse, Mitsuhiro
- Abstract
Abstract: To determine the mechanism of sensitivity to low-temperature exposure (20°C for 3h) and corticotropin-releasing factor (CRF) induced increased homeothermy, we investigated gene transcripts of putative thermogenic proteins and mitochondrial fatty acid (FA)-oxidation enzymes in neonatal chicks. The hypothalamic–pituitary–adrenal (HPA) axis in low-temperature-exposed neonatal chicks was activated by central administration of CRF. Neonatal chicks showed hypothermia on exposure to low-temperature, with no enhancement of HPA axis and gene transcripts of avian adenine nucleotide translocator, avian uncoupling protein, avian peroxisome-proliferator-activated receptor-γ co-activator-1α, and mitochondrial FA transport and oxidation enzymes in vital organs. However, central administration of CRF activated the HPA axis under low environmental temperature and induced increased homeothermy that was associated with the enhancement of gene transcripts and activities of mitochondrial FA-oxidation enzymes in the liver and heart.
- Subjects
CORTICOTROPIN releasing hormone; FATTY acids; OXIDATION; ENZYMES; HYPOTHALAMIC-pituitary-adrenal axis; HYPOTHERMIA
- Publication
FEBS Letters, 2008, Vol 582, Issue 20, p3052
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.07.050