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- Title
Control of 4E-BP1 expression in mouse brown adipose tissue by the <f>β<sub>3</sub></f>-adrenoceptor
- Authors
Lehr, Lorenz; Kuehne, Françoise; Arboit, Patrizia; Giacobino, Jean-Paul; Poulin, Francis; Muzzin, Patrick; Jimenez, Maria
- Abstract
Knockout of the translation inhibitor 4E-BP1 induces an overexpression of uncoupling protein-1 (UCP1) [Nature Medicine 7 (2001) 1128]. A possible inverse control of UCP1 and 4E-BP1 expressions in mouse brown adipose tissue was investigated. Cold-exposure, which increases the expression of UCP1, decreased that of 4E-BP1 mRNA in wild type but not in <f>β1/β2/β3</f>-adrenoceptor knockout mice. Administration of the <f>β3</f>-adrenoceptor agonist CL 316 246 decreased 4E-BP1 mRNA by 75% and protein by 41% after 6 and 48 h, respectively. Our data are the first report of a regulation by the <f>β3</f>-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis.
- Subjects
ADIPOSE tissues; CONNECTIVE tissues; CELLULITE; BROWN adipose tissue
- Publication
FEBS Letters, 2004, Vol 576, Issue 1/2, p179
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.08.081