We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Next-generation sequencing of primary testicular lymphoma and relapse in the glans penis after prophylactic radiation therapy: a rare case report.
- Authors
Ishibashi, Naoya; Nakanishi, Yoko; Maebayashi, Toshiya; Miura, Katsuhiro; Ohni, Sumie; Masuda, Shinobu; Amano, Yasuo; Okada, Masahiro
- Abstract
Background: Primary testicular lymphoma (PTL) is relatively rare. The contralateral testis is a common site of PTL relapse; therefore, once complete remission is achieved, radiation therapy (RT) is administered to the contralateral testis to prevent relapse. Case presentation: A 76-year-old man was diagnosed with PTL and received RT as described above. However, despite achieving and maintaining complete remission, a mass diagnosed as diffuse large B-cell lymphoma by tissue biopsy developed in the glans penis 6.5 years after prophylactic RT. We investigated whether the glans penile lymphoma was PTL relapse or a new malignancy by genomic analysis using next-generation sequencing of DNA extracted from two histopathological specimens. Conclusions: We found the same variant allele fraction in four somatic genes (MYD88, IL7R, BLNK, and FLT3) at similar frequencies, indicating that the glans penile lymphoma had the same origin as the PTL. To the best of our knowledge, this is the first case report of PTL relapse in the glans penis.
- Subjects
NUCLEOTIDE sequencing; DIFFUSE large B-cell lymphomas; RADIOTHERAPY; PENIS; LYMPHOMAS; MYC oncogenes; SPERMATOGENESIS
- Publication
Diagnostic Pathology, 2024, Vol 19, Issue 1, p1
- ISSN
1746-1596
- Publication type
Case Study
- DOI
10.1186/s13000-024-01498-x