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- Title
Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort.
- Authors
Ose, J; Fortner, R T; Schock, H; Peeters, P H; Onland-Moret, N C; Bueno-de-Mesquita, H B; Weiderpass, E; Gram, I T; Overvad, K; Tjonneland, A; Dossus, L; Fournier, A; Baglietto, L; Trichopoulou, A; Benetou, V; Trichopoulos, D; Boeing, H; Masala, G; Krogh, V; Matiello, A
- Abstract
Background:Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.Methods:We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.Results:We observed no association between IGF-I and EOC overall or by tumour characteristics.Conclusions:In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
- Subjects
SOMATOMEDIN C; OVARIAN cancer; EPITHELIAL cell tumors; OVARIAN cancer diagnosis; SERODIAGNOSIS; CANCER risk factors
- Publication
British Journal of Cancer, 2015, Vol 112, Issue 1, p162
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/bjc.2014.566