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- Title
Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon tetrachloride–induced liver damage in experimental model.
- Authors
Qujeq, Durdi; Abassi, Roya; Faeizi, Farideh; Parsian, Hadi; Faraji, Alieh Sohan; Taheri, Hassan; Tatar, Mohsen; Elmi, Marym M; Halalkhor, Sohhrab
- Abstract
The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes, aminotransferases, compared with the untreated group.
- Subjects
GRANULOCYTES; COLONY-stimulating factors (Physiology); CARBON tetrachloride; LIVER diseases; AMINOTRANSFERASES; INTRAPERITONEAL injections; DRUG administration
- Publication
Toxicology & Industrial Health, 2013, Vol 29, Issue 6, p498
- ISSN
0748-2337
- Publication type
Article
- DOI
10.1177/0748233712440136