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- Title
Inflammation and migration.
- Authors
Schubert, Charlotte
- Abstract
This article informs that cells derived from the bone marrow spawn the gastric tumors induced by Helicobacter pylori. To investigate the source of gastric tumors, the researchers used a mouse strain that develops inflammation and then cancer when infected with H. felis. The researchers irradiated the mice to eliminate their bone marrow, and then transplanted the mice with marrow cells expressing galactosidase. The engrafted cells began to differentiate, resembling gastric epithelial cells. But the cells were not quite normal, they grew quickly, had distorted shapes, and eventually gave rise to cancerous tumors
- Subjects
BONE marrow cancer; ONCOLOGY; IMMUNE system; HELICOBACTER pylori; BONE marrow cells; EPITHELIAL cells
- Publication
Nature Medicine, 2005, Vol 11, Issue 1, p21
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm0105-21