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- Title
Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates.
- Authors
Brawn, Peter N.; Speights, V. O.; Kuhl, Daniel; Riggs, Mark; Spiekerman, A. Michael; McCord, Robert G.; Scott Coffield, K.; Stewart, David T.; Lind, Mary L.; Brawn, P N; Kuhl, D; Riggs, M; Spiekerman, A M; McCord, R G; Coffield, K S; Stewart, D T; Lind, M L
- Abstract
Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger than 1 ml. Eleven untrimmed prostates weighed 80 g or more and eight had elevated PSA levels (more than 4.0 ng/ml): five of eight without CAP, two of two with CAP less than 1 ml, and one of one with CAP larger than 1 ml. Ninety-four whole untrimmed prostates weighed less than 80 g and 20 had elevated PSA levels: ten of 60 without CAP, two of 26 with CAP less than 1 ml, and eight of eight with CAP larger than 1 ml. This study suggests that PSA levels from patients with untrimmed prostates weighing 80 g or more (equivalent to a 60-g trimmed prostate) are usually elevated regardless whether CAP is present. However, CAP less than 1 ml, in untrimmed prostates less than 80 g, usually does not elevate PSA levels whereas CAP larger than 1 ml usually does (P less than 0.0001). The likelihood that elevated PSA levels, from patients with untrimmed prostates less than 80 g, are due to CAP larger than 1 ml increases as the PSA level increases.
- Subjects
ANTHROPOMETRY; AUTOPSY; PROSTATE; PROSTATE tumors; PROSTATITIS; STATISTICS; TUMOR antigens; PROSTATE-specific antigen
- Publication
Cancer (0008543X), 1991, Vol 68, Issue 7, p1592
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19911001)68:7<1592::AID-CNCR2820680721>3.0.CO;2-M