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- Title
The development of neutralizing antibodies in a patient receiving subcutaneous recombinant and natural interleukin-2.
- Authors
Kirchner, Hartmut; Körfer, Alfred; Evers, Pauline; Szamel, Marta M.; Knüver-Hopf, Joseph; Mohr, Harald; Franks, Chris R.; Pohl, Ulrich; Resch, Klaus; Hadam, Martin; Poliwoda, Hubert; Atzpodien, Jens; Kirchner, H; Körfer, A; Evers, P; Szamel, M M; Knüver-Hopf, J; Mohr, H; Franks, C R; Pohl, U
- Abstract
Systemic administration of interleukin-2 (IL-2) in humans may induce antibodies specific to IL-2. The case is reported of a patient with metastatic rectal carcinoma who was treated with long-term subcutaneous IL-2 and a combination of subcutaneous IL-2 and interferon-alpha 2b (IFN-alpha 2b). This patient developed nonneutralizing and neutralizing anti-IL-2 antibodies recognizing both the recombinant and natural cytokine. Detectable serum levels of neutralizing antibodies were accompanied by the inhibition of immune responsiveness to systemic IL-2 in vivo.
- Publication
Cancer (0008543X), 1991, Vol 67, Issue 7, p1862
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19910401)67:7<1862::AID-CNCR2820670708>3.0.CO;2-R