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- Title
The CXC Chemokine MIG/CXCL9 Is Important in Innate Immunity against Streptococcus pyogenes.
- Authors
Egesten, Arne; Eliasson, Mette; Johansson, Helena M.; Olin, Anders I.; Mörgelin, Matthias; Mueller, Anja; Pease, James E.; Frick, Inga-Maria; Björck, Lars
- Abstract
Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in humans and is also a starting point for invasive S. pyogenes infection. Here, we describe that tonsil fluid from patients with streptococcal pharyngitis contains high amounts of the interferon (IFN)-dependent CXC chemokine known as monokine induced by IFN-γ (MIG)/CXCL9. Also in vitro, inflamed pharyngeal epithelium produced large amounts of MIG/CXCL9 in the presence of bacteria. The CXC chemokines MIG/CXCL9, IFN-inducible protein-10/CXCL10, and IFN-inducible T cell a-chemoattractant/CXCL11 all showed antibacterial activity against S. pyogenes, and inhibition of MIG/CXCL9 expression reduced the antibacterial activity at the surface of inflamed pharyngeal cells. S. pyogenes of the clinically important M1 serotype secrets the protein streptococcal inhibitor of complement (SIC), which inhibited the antibacterial activity of the chemokines. As exemplified by S. pyogenes pharyngitis, the data identify a novel innate defense mechanism against invasive bacteria on epithelial surfaces.
- Subjects
PHARYNGITIS; STREPTOCOCCUS pyogenes; BACTERIAL diseases; CHEMOKINES; INTERFERONS; EPITHELIUM
- Publication
Journal of Infectious Diseases, 2007, Vol 195, Issue 5, p684
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/510857