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- Title
The minimum effective concentration (MEC90 ) of ropivacaine for ultrasound-guided supraclavicular brachial plexus block.
- Authors
Fang, G.; Wan, L.; Mei, W.; Yu, H. H.; Luo, A. L.
- Abstract
The aim of this study was to determine the minimum effective concentration of ropivacaine for ultrasound-guided supraclavicular brachial plexus block. Fifty-one patients undergoing arm surgery received double-injection ultrasound-guided supraclavicular block using ropivacaine 40 ml. The concentration of ropivacaine administered to each patient started at 0.225% and then depended on the response of the previous one, based on a biased coin design up-and-down sequential method. In case of failure, the ropivacaine concentration was increased by 0.025% w/v in the next subject. In the case of a successful block, the next patient was randomised to the same concentration or a concentration 0.025% w/v less. Success was defined as complete sensory blockade of the brachial plexus 30 min after the block together with pain-free surgery. The minimum effective ropivacaine concentration in 90% of subjects was 0.257% w/v (95% CI 0.241-0.280%).
- Subjects
ROPIVACAINE; BRACHIAL plexus block; DIAGNOSTIC ultrasonic imaging; BRACHIAL plexus diseases; RANDOMIZED controlled trials; ARM surgery; THERAPEUTICS; AMIDES; COMPARATIVE studies; LOCAL anesthetics; RESEARCH methodology; MEDICAL cooperation; RESEARCH; ULTRASONIC imaging; EVALUATION research
- Publication
Anaesthesia, 2016, Vol 71, Issue 6, p700
- ISSN
0003-2409
- Publication type
journal article
- DOI
10.1111/anae.13445