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- Title
High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies.
- Authors
Jun Kang; Jeong Hyun Cho; Cheol Won Suh; Dae Ho Lee; Heung Bum Oh; Yong Hak Sohn; Hyun Sook Chi; Chan Jeong Park; Sung Soo Jang; Kyoo Hyung Lee; Je-Hwan Lee; Jung Hee Lee; Sang Wook Lee; Young Hwa Chung; Tae Hyup Kim; Hai-Rim Shin; Jooryung Huh
- Abstract
We performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.
- Subjects
KOREA; HEPATITIS B treatment; HEPATITIS C treatment; VIRAL disease treatment; HEMATOPOIESIS; CASE-control method
- Publication
Annals of Hematology, 2011, Vol 90, Issue 2, p159
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-010-1055-5