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- Title
Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.
- Authors
Vandiedonck C; Capdevielle C; Giraud M; Krumeich S; Jais JP; Eymard B; Tranchant C; Gajdos P; Garchon HJ
- Abstract
OBJECTIVE: Our objective was to investigate a role of the intracellular tyrosine phosphatase PTPN22*R620W variant in autoimmune myasthenia gravis (MG), considering disease heterogeneity. METHODS: We used a case-control design, comparing 470 patients and 296 controls, all French whites. Patients were categorized depending on the presence of a thymoma and serum anti-titin antibodies. RESULTS: The 620W risk allele was increased in 293 nonthymoma patients without anti-titin antibodies (odds ratio, 1.97; 95% confidence interval, 1.32-2.97, p = 0.00059) but not in nonthymoma patients with anti-titin antibodies or in thymoma patients. INTERPRETATION: Our genetic findings strengthen the concept that these groups of patients correspond to etiologically distinct disease entities.
- Publication
Annals of Neurology, 2006, Vol 59, Issue 2, p404
- ISSN
0364-5134
- Publication type
Journal Article