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- Title
Saccade velocity is controlled by polyglutamine size in spinocerebellar ataxia 2.
- Authors
Luis Velázquez‐Pérez; Carola Seifried; Nieves Santos‐Falcón; Michael Abele; Ulf Ziemann; Luis Enrique Almaguer; Edilberto Martínez‐Góngora; Gilberto Sánchez‐Cruz; Nalia Canales; Ruth Pérez‐González; Mercedes Velázquez‐Manresa; Bettina Viebahn; Sebastian Von Stuckrad‐Barre; Michael Fetter; Thomas Klockgether; Georg Auburger
- Abstract
We assessed maximal saccade velocity (MSV) in 82 spinocerebellar ataxia type 2 (SCA2) patients and 80 controls, correlating it to disease duration, polyglutamine expansion size, age at onset, ataxia score, age, and sex. Little overlap with normal values was found even at earliest stages. Stepwise linear regression analysis showed that 60‐degree MSV was strongly influenced by polyglutamine size and less by disease duration, whereas the reverse was found for ataxia score. Saccade velocity thus is a sensitive, quite specific, and objective endophenotype, useful to search polyglutamine modifier genes. Ann Neurol 2004;56:444–447
- Publication
Annals of Neurology, 2004, Vol 56, Issue 3, p444
- ISSN
0364-5134
- Publication type
Article