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- Title
Long-term risk of cholangitis in patients with metal stents for malignant biliary obstruction.
- Authors
Pola S; Muralimohan R; Cohen B; Fehmi SM; Savides TJ; Pola, Suresh; Muralimohan, Ramya; Cohen, Benjamin; Fehmi, Syed M Abbas; Savides, Thomas J
- Abstract
<bold>Background: </bold>Patients with malignant biliary obstruction are commonly living longer than previously due to improved oncologic therapies, often exceeding expected times of self-expanding metal stent patency.<bold>Aims: </bold>The purpose of this study was to assess the long-term risk and impact of cholangitis in these patients.<bold>Methods: </bold>Retrospective review of electronic medical records at an academic medical center.<bold>Results: </bold>One hundred and one patients had a self-expanding metal stent placed for malignant biliary obstruction. The median survival after SEMS was 214 days. Of these patients, 22 % developed at least one episode of cholangitis requiring inpatient admission, 20 % (9/45) of patients were hospitalized for cholangitis at 6 months, 40 % (8/20) at 1 year, and 75 % (3/4) at 2 years. All of the (8/8) patients receiving chemotherapy prior to hospitalization for cholangitis experienced delays in subsequent chemotherapy. Follow-up of 36 episodes of cholangitis revealed a 14 % 30-day mortality.<bold>Conclusions: </bold>Cholangitis develops commonly in long-term survivors with self-expanding metal stents for malignant biliary obstruction, and is associated with delays in chemotherapy and a 14 % 30-day mortality.
- Publication
Digestive Diseases & Sciences, 2012, Vol 57, Issue 10, p2693
- ISSN
0163-2116
- Publication type
journal article