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- Title
Expression and Significance of Twist, E-Cadherin, and N-Cadherin in Gastrointestinal Stromal Tumors.
- Authors
Ding, Jie; Zhang, Zhongmin; Pan, Yang; Liao, Guoqing; Zeng, Liang; Chen, Senlin
- Abstract
Background: Twist, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of cancer. Aims: To investigate the expression and clinical significance of Twist, E-cadherin, and N-cadherin in gastrointestinal stromal tumors (GISTs). Methods: The expression of Twist, E-cadherin, and N-cadherin in GISTs was determined by immunohistochemistry, and their relationship with clinicopathological characteristics was analyzed. Results: The positive rates of Twist, E-cadherin, and N-cadherin in GISTs were 66.7 % (52/78), 35.9 % (28/78), and 75.6 % (59/78), respectively. Twist was expressed significantly more in GISTs with distant metastasis or local invasion ( p < 0.05). Although E-cadherin was expressed significantly less in cases of GISTs with distant metastasis ( p < 0.05), expression of N-cadherin did not differ significantly according to clinical and pathological characteristics ( p > 0.05). Expression of Twist was correlated positively with E-cadherin ( rs = −0.253, p = 0.026) and negatively with N-cadherin ( rs = 0.245, p = 0.030). Conclusions: Twist was expressed significantly more and E-cadherin significantly less in GISTs with metastasis, and expression of both was closely related to metastasis of GISTs.
- Subjects
GASTROINTESTINAL stromal tumors; GENE expression; CADHERINS; METASTASIS; HELIX-loop-helix motifs; IMMUNOHISTOCHEMISTRY
- Publication
Digestive Diseases & Sciences, 2012, Vol 57, Issue 9, p2318
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-012-2186-4