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- Title
Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia: A Potential Cytogenetic and Flow Cytometry Pitfall.
- Authors
Rowan, Daniel J.; Logunova, Valentina; van Tuinen, Peter; Olteanu, Horatiu; Peterson, Jess F.
- Abstract
Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry and fluorescence in situ hybridization (FISH). Bone marrow histology in conjunction with immunohistochemical stains was also evaluated. A population of atypical cells with blast-like morphology was present in the peripheral blood. Flow cytometry showed a 9% population of CD45 dim positive, CD13 partial positive, and CD15 variably positive cells. Peripheral blood FISH analysis revealed deletion 7q, gain of 8q, and deletions 16q and 17q in 32.5% to 36% of 200 interphase cells analyzed. The bone marrow biopsy showed cohesive groups of cytokeratin AE1/AE3 positive cells. Our report demonstrates that circulating carcinoma cells can mimic a high-grade myeloid neoplasm morphologically and by flow cytometry and FISH analysis.
- Subjects
BREAST cancer; METASTASIS; ACUTE myeloid leukemia; FLOW cytometry; FLUORESCENCE in situ hybridization; CD45 antigen; CELL migration; DIAGNOSIS
- Publication
International Journal of Surgical Pathology, 2017, Vol 25, Issue 1, p87
- ISSN
1066-8969
- Publication type
Case Study
- DOI
10.1177/1066896916664986