We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mono- and Dimeric Naphthalenones from the Marine-Derived Fungus Leptosphaerulina chartarum 3608.
- Authors
Zhang, Panpan; Li, Jing; Luo, Guangyuan; Chen, Senhua; Liu, Lan; Jia, Chunxiu; Lang, Jiajia; Yan, Sujun
- Abstract
Five new naphthalenones, two enantiomers (−)-<bold>1</bold> and (+)-<bold>1</bold> leptothalenone A, (−)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2<italic>H</italic>-naphthalen-1-one ((−)-<bold>2</bold>), (4<italic>S</italic>, 10<italic>R</italic>, 4’<italic>S</italic>)-leptotha-lenone B (<bold>5</bold>), (4<italic>R</italic>, 10<italic>S</italic>, 4’<italic>S</italic>)-leptothalenone B (<bold>6</bold>), and a new isocoumarine, 6-hydroxy-5,8-dimethoxy-3-methyl-1<italic>H</italic>-isochromen-1-one (<bold>4</bold>), along with two known compounds (+)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2<italic>H</italic>-naphthalen-1-one ((+)-<bold>2</bold>) and (+)-10-norparvulenone (<bold>3</bold>) were isolated from the marine-derived fungus <italic>Leptosphaerulina chartarum</italic> 3608. The structures of new compounds were elucidated by HR-ESIMS, NMR, and ECD analysis. All compounds were evaluated for cytotoxicity and anti-inflammatory activity. Compound <bold>6</bold> showed moderate anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in lipopolysaccharide-stimulated RAW264.7 cells, with an IC50 value of 44.5 μM.
- Subjects
LEPTOSPHAERULINA; NAPHTHALENONES; ACREMONIUM; POLYKETIDES; METABOLITES
- Publication
Marine Drugs, 2018, Vol 16, Issue 5, p173
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16050173