We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic variation in the myeloperoxidase gene and cognitive impairment in Multiple Sclerosis.
- Authors
Manna, I.; Valentino, P.; La Russa, A.; Condino, F.; Nisticò, R.; Liguori, M.; Clodomiro, A.; Andreoli, V.; Pirritano, D.; Cittadella, R.; Quattrone, A.
- Abstract
There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to β-amyloid deposition. We investigated a functional biallelic (G/A) polymorphism in the promoter region (-463) of the MPO gene in 465 patients affected by MS, divided into 204 cognitively normal and 261 impaired. We did not find significant differences in allele or genotype distributions between impaired and preserved MS patients. Our findings suggest that MPO polymorphism is not a risk factor for cognitive impairment in MS.
- Subjects
MEDICAL research; MULTIPLE sclerosis; COGNITION disorders; GENES; GENETIC polymorphisms
- Publication
Journal of Negative Results in Biomedicine, 2006, Vol 5, p3
- ISSN
1477-5751
- Publication type
Article
- DOI
10.1186/1477-5751-5-3