We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical aspects of cytotoxicity of nitroaromatic explosives: a review.
- Authors
Nemeikaitė-Čėnienė, Aušra; Miliukienė, Valė; Šarlauskas, Jonas; Maldutis, Evaldas; Čėnas, Narimantas
- Abstract
Nitroaromatic explosives and their degradation products are toxic environmental pollutants. In this paper, we summarize the available data on the chemical aspects of toxicity of the classical and the new generation nitroaromatic explosives, i.e. their flavoenzyme-catalyzed single- and two-electron reduction and the impact of these reactions on the mammalian cell cytotoxicity of explosives. The leading role of the oxidative stress-type cytotoxicity of nitroaromatic explosives has been demonstrated in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) and, possibly, in mouse splenocytes.
- Subjects
NITROAROMATIC compounds; POLLUTANTS; TOXICITY testing; FLAVOPROTEINS; ELECTRONS; OXIDATIVE stress; LEUKEMIA
- Publication
Chemija, 2006, Vol 17, Issue 2/3, p34
- ISSN
0235-7216
- Publication type
Article