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- Title
CTRP3/AMPK pathway plays a key role in the anti-hypertrophic effects of cyanidin-3-O-glucoside by inhibiting the inflammatory response.
- Authors
Xueli Zhang; Xiaoyi Qin
- Abstract
Background. Cardiac hypertrophy can be a pathological process that impairs heart function. Anthocyanins are a well-characterized type of natural antioxidant, and recent studies have shown that this type of compound has potential cardioprotective effects against different disorders, such as cardiac hypertrophy. Objectives. We assessed the anti-hypertrophy potential of cyanidin-3-O-glucoside (C3G) and the mechanism associated with any observed effects. Materials and methods. Hypertrophy symptoms were induced using the transverse aortic constriction (TAC) operation in vivo and angiotensin II (Ang II) in vitro. The effect of C3G on the development of hypertrophic symptoms was then determined. Moreover, we examined the influence of CTRP3 inhibition on the anti-hypertrophy function of C3G. Results. The TAC operation induced cardiac fibrosis and heart weight increase, which was associated with increased production of cytokines and suppressed activity of the CTRP3/AMPK pathway. The impairments of heart structure and function were attenuated by C3G. Angiotensin II induced size increases of neonatal rat cardiomyocytes (NRCMs) in vitro, and this effect was inhibited by C3G. Furthermore, the inhibition of CTRP3 counteracted the function of C3G by promoting NRCM hyperplasia and inflammation. Conclusions. The results of the current study showed that the activation of CTRP3 contributed to the antihypertrophy effects of C3G.
- Subjects
CARDIAC hypertrophy; HEART fibrosis; AMP-activated protein kinases; INFLAMMATION; SYMPTOMS; ANGIOTENSIN II
- Publication
Advances in Clinical & Experimental Medicine, 2024, Vol 33, Issue 8, p831
- ISSN
1899-5276
- Publication type
Article
- DOI
10.17219/acem/172546