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- Title
Extractable Perfluoroalkyl Carboxylic Acids and Sulfonates in Food Contact Materials: Development of a Simple Analytical Method with Ultrasonic Extraction, Dispersive Sorbent Clean-Up, and LC-MS/MS Quantification.
- Authors
Tran, Thi Lieu; Nguyen, Thi Anh Huong; Kieu, Thi Lan Phuong; Luu, Thi Huyen Trang; Do, Thi Thu Hang; Nguyen, Hieu Duc; Pham, Trung Quang; Nguyen, Huy Quang; Rupasinghe, Hasara Savindi; Tuyen, Le Huu; Nguyen, Thi Quynh Hoa; Hoang, Anh Quoc
- Abstract
Poly- and perfluoroalkyl substances (PFASs) have attracted great scientific attention because of their environmental persistence, bioaccumulation potentials, and toxicity. This study validated a simple and efficient sample preparation method for determining extractable PFASs, including 12 perfluoroalkyl carboxylic acids and 4 perfluoroalkyl sulfonates. The samples underwent ultrasonic extraction, and the extracts were cleaned up by dispersive solid-phase extraction technique with graphitized carbon if necessary. PFAS quantification was performed by a liquid chromatography-tandem mass spectrometry system. The instrument provided analytical signals for all target compounds with good repeatability (RSD < 15%), reproducibility (RSD < 20%), linearity (R2 > 0.99), and low detection limits (0.10–1.0 ng/mL). The validated method exhibited adequate recovery (70–115%), precision (RSD < 15%), and method detection limits (0.020–0.70 ng/g). This validated method was applied to analyze PFASs in several food packaging samples collected in Vietnam, showing very low levels (range 0.090–2.9 ng/g; median 0.72 ng/g) derived from unintentional sources.
- Subjects
FLUOROALKYL compounds; EXTRACTION techniques; CARBOXYLIC acids; FOOD packaging; DETECTION limit
- Publication
Journal of Analytical Chemistry, 2024, Vol 79, Issue 9, p1304
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934824700667