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- Title
Cutaneous Melanoma: An Overview of Physiological and Therapeutic Aspects and Biotechnological Use of Serine Protease Inhibitors.
- Authors
Boleti, Ana Paula De Araújo; Jacobowski, Ana Cristina; Monteiro-Alfredo, Tamaeh; Pereira, Ana Paula Ramos; Oliva, Maria Luiza Vilela; Maria, Durvanei Augusto; Macedo, Maria Lígia Rodrigues
- Abstract
Background: Metastatic melanoma stands out as the most lethal form of skin cancer because of its high propensity to spread and its remarkable resistance to treatment methods. Methods: In this review article, we address the incidence of melanoma worldwide and its staging phases. We thoroughly investigate the different melanomas and their associated risk factors. In addition, we underscore the principal therapeutic goals and pharmacological methods that are currently used in the treatment of melanoma. Results: The implementation of targeted therapies has contributed to improving the approach to patients. However, because of the emergence of resistance early in treatment, overall survival and progression-free periods continue to be limited. Conclusions: We provide new insights into plant serine protease inhibitor therapeutics, supporting high-throughput drug screening soon, and seeking a complementary approach to explain crucial mechanisms associated with melanoma.
- Subjects
PROGRESSION-free survival; SKIN cancer; HIGH throughput screening (Drug development); OVERALL survival; PROTEASE inhibitors
- Publication
Molecules, 2024, Vol 29, Issue 16, p3891
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29163891