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- Title
The Impact of Autosomal Dominant Polycystic Kidney Disease in Children: A Nephrological, Nutritional, and Psychological Point of View.
- Authors
Guarnaroli, Matteo; Padoan, Flavia; Fava, Cristiano; Benetti, Maria Giulia; Brugnara, Milena; Pietrobelli, Angelo; Piacentini, Giorgio; Pecoraro, Luca
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence of epigenetic mechanisms in modulating gene expression and disease progression in ADPKD. Furthermore, it proposes to examine the pathological characteristics of this condition at the nephrological, cardiovascular, nutritional, and psychological levels, emphasizing that the follow-up of patients with ADPKD should be multidisciplinary from a young pediatric age.
- Subjects
POLYCYSTIC kidney disease; CYSTIC kidney disease; PEDIATRIC nephrology; KIDNEY failure; GENE expression
- Publication
Biomedicines, 2024, Vol 12, Issue 8, p1823
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines12081823