We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of Extracellular Vesicles in Crohn's Patients on Adalimumab Who Received COVID-19 Vaccination.
- Authors
De Luca, Maria; Musio, Biagia; Balestra, Francesco; Arrè, Valentina; Negro, Roberto; Depalo, Nicoletta; Rizzi, Federica; Mastrogiacomo, Rita; Panzetta, Giorgia; Donghia, Rossella; Pesole, Pasqua Letizia; Coletta, Sergio; Piccinno, Emanuele; Scalavino, Viviana; Serino, Grazia; Maqoud, Fatima; Russo, Francesco; Orlando, Antonella; Todisco, Stefano; Mastrorilli, Pietro
- Abstract
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) affecting the gastrointestinal tract that can also cause extra-intestinal complications. Following exposure to the mRNA vaccine BNT162b2 (Pfizer-BioNTech) encoding the SARS-CoV-2 Spike (S) protein, some patients experienced a lack of response to the biological drug Adalimumab and a recrudescence of the disease. In CD patients in progression, resistant to considered biological therapy, an abnormal increase in intestinal permeability was observed, more often with a modulated expression of different proteins such as Aquaporin 8 (AQP8) and in tight junctions (e.g., ZO-1, Claudin1, Claudin2, Occludin), especially during disease flares. The aim of this study is to investigate how the SARS-CoV-2 vaccine could interfere with IBD therapy and contribute to disease exacerbation. We investigated the role of the SARS-CoV-2 Spike protein, transported by extracellular vesicles (EVs), and the impact of various EVs components, namely, exosomes (EXOs) and microvesicles (MVs), in modulating the expression of molecules involved in the exacerbation of CD, which remains unknown.
- Subjects
CROHN'S disease; AQUAPORINS; DISEASE relapse; INFLAMMATORY bowel diseases; TIGHT junctions; OCCLUDINS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8853
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168853