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- Title
Peroxisome Proliferator-Activated Receptor α Ligands Increase Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 Expression in Vascular Endothelial Cells.
- Authors
HAYASHIDA, KAZUTAKA; KUME, NORIAKI; MINAMI, MANABU; KATAOKA, HIROHARU; MORIMOTO, MASAFUMI; KITA, TORU
- Abstract
A bstract: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a receptor for atherogenic oxidized LDL expressed in vascular endothelial cells, smooth muscle cells, and macrophages. Peroxiosme proliferator-activated receptors (PPARs) include subfamilies PPARα and PPARγ, which are expressed in endothelial cells and involved in transcriptional regulation of a large number of genes that affect lipoprotein and fatty acid metabolism as well as inflammation. We therefore explored the effects of PPARα and PPARγ ligands on expression of LOX-1. Treatment of cultured bovine aortic endothelial cells (BAECs) with PPARα ligands (fenofibrate and WY14643) remarkably upregulated LOX-1 expression, which was detected by western and northern blot analyses. LOX-1 promoter-reporter gene assay showed that PPARα ligands activate transcription of the LOX-1 gene. PPARγ ligands, in contrast, did not significantly affect LOX-1 expression in BAECs. PPARα appears to be a key regulator in promoting LOX-1 expression in BAECs. Upregulated expression of LOX-1 may modulate the catabolism of oxidized LDL and atherosclerotic progression.
- Publication
Annals of the New York Academy of Sciences, 2001, Vol 947, Issue 1, p370
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2001.tb03965.x