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- Title
5-HT<sub>4</sub> Receptors: Cloning and Expression of New Splice Variants.
- Authors
CLAEYSEN, S.; FAYE, P.; SEBBEN, M.; TAVIAUX, S.; BOCKAERT, J.; DUMUIS, A.
- Abstract
ABSTRACT: On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses in several tissues is due to differences in coupling efficiency rather than to the presence of different 5-HT4 receptor isoforms.
- Publication
Annals of the New York Academy of Sciences, 1998, Vol 861, Issue 1, p49
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1998.tb10172.x