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- Title
Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome.
- Authors
Juneja, Deven; Mohan, S.; Veturi, Vivek V.; Gopal, Palepu B.
- Abstract
Results of the PROWESS trial suggested that heparin may reduce the efficacy of recombinant human activated protein C (rhAPC) and the XPRESS study also showed increased bleeding complications in patients receiving heparin with rhAPC. Although it has been shown that heparin prophylaxis may be used along with rhAPC, no study has shown the interaction between continuous heparin infusion and rhAPC. Here, we report a case of severe sepsis with pulmonary embolism who was concurrently administered heparin and rhAPC infusions, with positive results and no bleeding complications.
- Subjects
HEPARIN; PROTEIN C; PULMONARY embolism; SEPSIS; HEMORRHAGE; ANTICOAGULANTS; INTENSIVE care units
- Publication
Indian Journal of Critical Care Medicine, 2009, Vol 13, Issue 3, p163
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/0972-5229.58544