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- Title
Anti-adipogenic effect of Glycoside St-E2 and Glycoside St-C1 isolated from the leaves of Acanthopanax henryi (Oliv.) Harms in 3T3-L1 cells.
- Authors
Han, Yo-Han; Li, Zhi; Um, Jae-Young; Liu, Xiang Qian; Hong, Seung-Heon
- Abstract
Acanthopanax henryi(Oliv.) Harms has been used in the treatment of arthritis, rheumatism, and abdominal pain. This study evaluated whether natural compounds isolated from the leaves ofA. henryi(Oliv.) Harms could inhibit adipocyte differentiation by regulating transcriptional factors such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα). AMP-activated protein kinase (AMPK) activity was also evaluated. Among the several compounds isolated from the leaves ofA. henryi(Oliv.) Harms, Glycoside St-C1 and Glycoside St-E2 significantly decreased lipid accumulation and the expressions of PPARγ and C/EBPα. Glycoside St-C1 and Glycoside St-E2 were found to activate AMPK when they regulated PPARγ and C/EBPα. Results confirmed that Glycoside St-C1 and Glycoside St-E2 isolated from the leaves ofA. henryi(Oliv.) Harms can inhibit adipogenesis through the AMPK-PPARγ-C/EBPα mechanism. Thus, this study suggests that Glycoside St-C1 and Glycoside St-E2 have a therapeutic effect due to activation of the AMPKα. Glycoside St-C1 and Glycoside St-E2 decreased lipid accumulation and the expressions of PPARγ and C/EBPα. Glycoside St-C1 and Glycoside St-E2 were found to activate AMPK.
- Subjects
ACANTHOPANAX; TREATMENT of arthritis; RHEUMATISM treatment
- Publication
Bioscience, Biotechnology & Biochemistry, 2016, Vol 80, Issue 12, p2391
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2016.1217150