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- Title
Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma.
- Authors
de Vos, J. P.; Burm, A. G. D.; Focker, A. P.; Boschloo, H.; Karsijns, M.; van der Waal, I.
- Abstract
Results of the treatment with a combination of carboplatin and piroxicam in seven dogs with advanced non-tonsillar oral squamous cell carcinoma (SCC) were retrospectively analysed. This multi-agent protocol was well tolerated by all dogs and resulted in a complete regression of the tumour without additional surgery in four of seven patients. Additional surgery was necessary to remove a metastatic lymph node in one dog and residual tumour in a second dog, which achieved a partial response following medical therapy. Median follow-up for all the dogs was 534 days, while the time-to-recurrence, time-to-progression and overall survival for this group of patients have not yet been reached. Our study, although limited in number of animals, suggests that this multiagent approach is a useful treatment option for oral non-tonsillarSCC in dogs and warrants wider application.
- Subjects
PIROXICAM; SQUAMOUS cell carcinoma; CANCER; LYMPH nodes; TUMORS; LABORATORY dogs
- Publication
Veterinary & Comparative Oncology, 2005, Vol 3, Issue 1, p16
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5810.2005.00065.x