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- Title
Comparing the Dynamic Flow Properties and Compaction Properties of Pharmaceutical Powder Mixtures.
- Authors
Leaper, Mark C.; Ali, Kashaf; Ingham, Andrew J.
- Abstract
The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30 % sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The mixtures were also analyzed using a shear cell, which gave flow functions that varied little between the samples. The feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient is demonstrated, without compromising desired powder characteristics. The study may also provide a useful method for assessing the suitability of new formulations for application as direct compression bases, as part of a wider range of powder flow tests.
- Subjects
PHARMACEUTICAL powders; MIXTURES; MANNITOL; CARBONATES; RHEOMETERS; GAS compressors
- Publication
Chemical Engineering & Technology, 2018, Vol 41, Issue 1, p102
- ISSN
0930-7516
- Publication type
Article
- DOI
10.1002/ceat.201600651