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- Title
Divergent Synthesis of Natural Derivatives of (+)‐Saxitoxin Including 11‐Saxitoxinethanoic Acid.
- Authors
Walker, James R.; Merit, Jeffrey E.; Thomas‐Tran, Rhiannon; Tang, Doris T. Y.; Du Bois, J.
- Abstract
The bis‐guanidinium toxins are a collection of natural products that display nanomolar potency against select isoforms of eukaryotic voltage‐gated Na+ ion channels. We describe a synthetic strategy that enables access to four of these poisons, namely 11‐saxitoxinethanoic acid, C13‐acetoxy saxitoxin, decarbamoyl saxitoxin, and saxitoxin. Highlights of this work include an unusual Mislow–Evans rearrangement and a late‐stage Stille ketene acetal coupling. The IC50 value of 11‐saxitoxinethanoic acid was measured against rat NaV1.4, and found to be 17.0 nm, similar to those of the sulfated toxins gonyautoxin II and III.
- Subjects
SAXITOXIN; GUANIDINE; EUKARYOTIC cells; ION channels; KETENES
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 6, p1703
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201811717