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- Title
Selective and Catalytic Hydrocarboxylation of Enamides and Imines with CO<sub>2</sub> to Generate α,α‐Disubstituted α‐Amino Acids.
- Authors
Ju, Tao; Fu, Qiang; Ye, Jian‐heng; Zhang, Zhen; Liao, Li‐li; Yan, Si‐shun; Tian, Xing‐yang; Luo, Shu‐ping; Li, Jing; Yu, Da‐gang
- Abstract
The first catalytic hydrocarboxylation of enamides and imines with CO2 to generate valuable α,α‐disubstituted α‐amino acids is reported. Notably, excellent chemo‐ and regio‐selectivity are achieved, significantly different from previous reports on β‐carboxylation of enamides, homocoupling or reduction of imines. Moreover, this transition‐metal‐free procedure exhibits low loading of an inexpensive catalyst, easily available substrates, mild reaction conditions, high efficiency, facile scalability and easy product derivatization, providing great potential for application in organic synthesis, pharmaceutical chemistry, and biochemistry.
- Subjects
IMINES; CARBON dioxide; AMINO acids; CARBOXYLATION; PHARMACEUTICAL chemistry
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 42, p14093
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201806874