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- Title
Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase.
- Authors
Sanzhaeva, Urikhan; Xu, Xuan; Guggilapu, Priyaankadevi; Tseytlin, Mark; Khramtsov, Valery V.; Driesschaert, Benoit
- Abstract
Abstract: Enzyme activities are well established biomarkers of many pathologies. Imaging enzyme activity directly in vivo may help to gain insight into the pathogenesis of various diseases but remains extremely challenging. In this communication, we report the use of EPR imaging (EPRI) in combination with a specially designed paramagnetic enzymatic substrate to map alkaline phosphatase activity with a high selectivity, thereby demonstrating the potential of EPRI to map enzyme activity.
- Subjects
ENZYMES; BIOMARKERS; ALKALINE phosphatase; CHEMICAL synthesis; PATHOGENIC microorganisms
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 36, p11875
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201806851