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- Title
Oxyfunctionalization of the Remote C−H Bonds of Aliphatic Amines by Decatungstate Photocatalysis.
- Authors
Schultz, Danielle M.; Lévesque, François; DiRocco, Daniel A.; Reibarkh, Mikhail; Ji, Yining; Joyce, Leo A.; Dropinski, James F.; Sheng, Huaming; Sherry, Benjamin D.; Davies, Ian W.
- Abstract
Aliphatic amines, oxygenated at remote positions within the molecule, represent an important class of synthetic building blocks to which there are currently no direct means of access. Reported herein is an efficient and scalable solution that relies upon decatungstate photocatalysis under acidic conditions using either H2O2 or O2 as the terminal oxidant. By using these reaction conditions a series of simple and unbiased aliphatic amine starting materials can be oxidized to value-added ketone products. Lastly, NMR spectroscopy using in situ LED-irradiated samples was utilized to monitor the kinetics of the reaction, thus enabling direct translation of the reaction into flow.
- Subjects
CARBON-hydrogen bonds; ALIPHATIC amines; TUNGSTATES; PHOTOCATALYSIS; SOLUTION (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 48, p15476
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201707537