We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats.
- Authors
Kojima, Ryosuke; Takakura, Hideo; Kamiya, Mako; Kobayashi, Eiji; Komatsu, Toru; Ueno, Tasuku; Terai, Takuya; Hanaoka, Kenjiro; Nagano, Tetsuo; Urano, Yasuteru
- Abstract
A sensitive bioluminogenic probe for highly reactive oxygen species (hROS), SO³H-APL, was developed based on the concept of dual control of bioluminescence emission by means of bioluminescent enzyme-induced electron transfer (BioLeT) and modulation of cell-membrane permeability. This probe enables non-invasive visualization of physiologically relevant amounts of hROS generated deep inside the body of living rats for the first time. It is expected to serve as a practical analytical tool for investigating a wide range of biological functions of hROS in vivo. The design concept should be applicable to other in vivo bioluminogenic probes.
- Subjects
REACTIVE oxygen species; BIOLUMINESCENCE; CHARGE exchange; LUMINESCENCE; MEMBRANE permeability (Biology)
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 49, p14981
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201507530