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- Title
Liverpool University Neuroleptic Side-Effect Rating Scale (LUNSERS) as a subjective measure of drug-induced parkinsonism and akathisia.
- Authors
Hee-Yeon Jung; Jong-Hoon Kim; Yong-Min Ahn; Seong-Chan Kim; Hwang, Samuel S.; Yong-Sik Kim
- Abstract
The Liverpool University Neuroleptic Side-Effect Rating Scale (LUNSERS) was examined for its usefulness as a subjective measure of drug-induced parkinsonism and akathisia. Eighty-three subjects were assessed using the LUNSERS, the Simpson–Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), before and after a 6-week treatment with olanzapine. Significant correlations were found between the changes in scores of parkinsonism items of LUNSERS and SAS. The changes in scores of akathisia item (restlessness), extrapyramidal side effects (EPS) subscale and psychic side-effects subscale of LUNSERS were significantly correlated with those of the BARS. ‘Shakiness’, one item of the EPS subscale of LUNSERS, correctly classified between parkinsonism and non-parkinsonism groups with 81.0% accuracy. A combination of four items included in EPS and psychic side-effect subscales of LUNSERS identified akathisia and non-akathisia groups with 76.2% accuracy. These results suggest that the EPS and psychic side-effect subscales of LUNSERS may be useful in screening for drug-induced parkinsonism and akathisia. Copyright © 2004 John Wiley & Sons, Ltd.
- Subjects
DRUG side effects; PARKINSON'S disease; TARDIVE dyskinesia; EXTRAPYRAMIDAL disorders; PSYCHOPHARMACOLOGY; PHARMACODYNAMICS
- Publication
Human Psychopharmacology: Clinical & Experimental, 2005, Vol 20, Issue 1, p41
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.655