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- Title
Comparative study of acute effects of single doses of fexofenadine, olopatadine, d -chlorpheniramine and placebo on psychomotor function in healthy volunteers.
- Authors
Kamei, Hiroyuki; Noda, Yukihiro; Ishikawa, Kazuhiro; Senzaki, Koji; Muraoka, Isao; Hasegawa, Yoshinori; Hindmarch, Ian; Nabeshima, Toshitaka
- Abstract
Since most classical (first-generation) antihistamines have undesirable sedative effects on the central nervous system (CNS), newer (second-generation) antihistamines have been developed to relieve the sedative effects and to improve the patient's quality of life. However, the psychomotor profiles of second-generation antihistamines are not fully elucidated. In this randomized, double-blind, crossover study, the acute effects of single doses of second-generation antihistamines, fexofenadine (120 mg) and olopatadine (10 mg), on cognitive and psychomotor performance were investigated in comparison with those of placebo and d -chlorpheniramine (4 mg), a first-generation antihistamine, using objective and subjective assessments, in 11 healthy Japanese volunteers. In a battery of psychomotor tests, d -chlorpheniramine impaired tracking ability in the compensatory tracking task and caused a reduction in behavioural activity as continuously measured by wrist actigraphy. Olopatadine, like d -chlorpheniramine, reduced the behavioural activity, while fexofenadine had no effect in any of the tests. No significant changes in the subjects' self-ratings of drowsiness were found with the three antihistamines. These results suggest that d -chlorpheniramine and olopatadine, but not fexofenadine, produce sedative effects on psychomotor performance, and that the CNS profile of fexofenadine is different from that of olopatadine. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
ANTIHISTAMINES; PHARMACODYNAMICS; FEXOFENADINE; CENTRAL nervous system; SEDATIVES
- Publication
Human Psychopharmacology: Clinical & Experimental, 2003, Vol 18, Issue 8, p611
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.538