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- Title
Cytotoxic Pentaketide-Sesquiterpenes from the Marine-Derived Fungus Talaromyces variabilis M22734.
- Authors
Tang, Lingzhi; Xia, Jinmei; Chen, Zhongwei; Wu, Xiaohui; Li, Guangyu; Lai, Qiliang; Shao, Zongze; Wang, Weiyi; Hong, Xuan
- Abstract
Talaromyces, a filamentous fungus widely distributed across terrestrial and marine environments, can produce a diverse array of natural products, including alkaloids, polyketones, and polyketide-terpenoids. Among these, chrodrimanins represented a typical class of natural products. In this study, we isolated three previously undescribed pentaketide-sesquiterpenes, 8,9-epi-chrodrimanins (1–3), along with eight known compounds (4–11). The structures of compounds 1–3 were elucidated using nuclear magnetic resonance (NMR) and mass spectrometry (MS), while their absolute configurations were determined through X-ray crystallography and electronic circular dichroism (ECD) computations. The biosynthetic pathways of compounds 1–3 initiate with 6-hydroxymellein and involve multiple stages of isoprenylation, cyclization, oxidation, and acetylation. We selected four strains of gastrointestinal cancer cells for activity evaluation. We found that compound 3 selectively inhibited MKN-45, whereas compounds 1 and 2 exhibited no significant inhibitory activity against the four cell lines. These findings suggested that 8,9-epi-chrodrimanins could serve as scaffold compounds for further structural modifications, potentially leading to the development of targeted therapies for gastric cancer.
- Subjects
POLYKETIDES; TALAROMYCES; NUCLEAR magnetic resonance; GASTROINTESTINAL cancer; X-ray crystallography; CIRCULAR dichroism
- Publication
Marine Drugs, 2024, Vol 22, Issue 6, p274
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22060274