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- Title
circRNAs in Endometrial Cancer—A Promising Biomarker: State of the Art.
- Authors
Włodarczyk, Karolina; Kuryło, Weronika; Pawłowska-Łachut, Anna; Skiba, Wiktoria; Suszczyk, Dorota; Pieniądz, Paulina; Majewska, Małgorzata; Boniewska-Bernacka, Ewa; Wertel, Iwona
- Abstract
Endometrial cancer (EC) is one of the most common malignant tumors among women in the 21st century, whose mortality rate is increasing every year. Currently, the diagnosis of EC is possible only after a biopsy. However, it is necessary to find a new biomarker that will help in both the diagnosis and treatment of EC in a non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical and stable long non-coding RNAs (lncRNAs) molecules, which are abundant in both body fluids and human tissues and are expressed in various ways. Considering the new molecular classification of EC, many studies have appeared, describing new insights into the functions and mechanisms of circRNAs in EC. In this review article, we focused on the problem of EC and the molecular aspects of its division, as well as the biogenesis, functions, and diagnostic and clinical significance of circRNAs in EC.
- Subjects
CIRCULAR RNA; ENDOMETRIAL cancer; LINCRNA; HUMAN body; BODY fluids; TWENTY-first century
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6387
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126387