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- Title
Rectovaginal fistula model in the New Zealand white rabbit.
- Authors
Aungst, Matthew J.; Fischer, John R.; Bonhage, Michael R.; Albright, Todd S.; Noel, Kathleen A.; Wright, Johnnie
- Abstract
The purpose of this study was to create an animal model to study rectovaginal fistula repair. Fourteen New Zealand white rabbits underwent surgical creation of a rectovaginal fistula. The technique was developed with a pilot study conducted on the first two animals, then standardized and performed on the remaining 12 rabbits. The standardized technique included making a defect in the rectovaginal septum using a 3-mm skin punch then splinting the defect with 6-mm tubing for 2 weeks. Using the standardized technique, a fistula was successfully created in all 12 rabbits ranging from 1 to 5 mm (mean = 2.8 mm, SD = 1.1). A 95% tolerance interval was calculated for the model and predicted that a successful fistula can be created ranging from 0.3 to 5.2 mm in 85% of attempts with the model. The New Zealand white rabbit is a promising animal model to study rectovaginal fistula repair.
- Subjects
FISTULA; VAGINAL surgery; VAGINAL diseases; RABBITS; ANIMAL models in research; THERAPEUTICS
- Publication
International Urogynecology Journal, 2010, Vol 21, Issue 7, p885
- ISSN
0937-3462
- Publication type
Article
- DOI
10.1007/s00192-010-1118-0