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- Title
Risk of liver-associated morbidity and mortality in a cohort of HIV and HBV coinfected Han Chinese.
- Authors
Yang, R.; Gui, X.; Xiong, Y.; Gao, S.; Zhang, Y.; Deng, L.; Liang, K.; Yan, Y.; Rong, Y.
- Abstract
Objectives: To investigate the incidence and risk factors of liver-associated morbidity and mortality in Han Chinese patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection. Methods: A retrospective study was conducted. Results: Of the 255 subjects with HIV and HBV coinfection, 181 (71.0%) received lamivudine-based combined antiretroviral therapy (cART). Of the patients, 49/255 (19.2%) developed advanced liver diseases (ALDs) (during 5.2 years): 30 patients developed clinically overt cirrhosis, 10 developed hepatocellular carcinoma and 9 developed severe reactivation of a preexisting chronic hepatitis B. Baseline CD4 cell count <200 cell/mm ( P = 0.013, OR = 6.503), baseline alanine aminotransferase (ALT) elevation ( P = 0.011, OR = 14.456), and longer cumulated time with detectable HIV RNA ( P = 0.008, OR = 1.814) and HBV DNA ( P = 0.014, OR = 1.536) were risk factors for ALDs development, while CD4 cell count changes ≥150 cells/mm within 3 months ( P = 0.039, OR = 0.049) and the use of lamivudine-based cART ( P = 0.030, OR = 0.034) were protective against ALDs development. Conclusions: ALDs was common among HIV and HBV coinfected Han Chinese patients. Lamivudine-based cART was beneficial in terms of sustained HBV viral suppression and resulted in less incidence of ALDs.
- Subjects
CHINA; LAMIVUDINE; ACADEMIC medical centers; AGE distribution; ANALYSIS of variance; EPIDEMIOLOGY; HEPATITIS B; HIV infections; LIVER diseases; SCIENTIFIC observation; POLYMERASE chain reaction; REGRESSION analysis; SEX distribution; STATISTICS; COMORBIDITY; LOGISTIC regression analysis; DATA analysis; ALANINE aminotransferase; DISEASE incidence; RETROSPECTIVE studies; THERAPEUTICS
- Publication
Infection, 2011, Vol 39, Issue 5, p427
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-011-0145-1