We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetics of disc degeneration.
- Authors
Chan, Danny; Youqiang Song; Pak Sham; Cheung, Kenneth M. C.
- Abstract
Low back pain from degenerative disc disease (DDD) is one of the most common disorders seen in general and orthopaedic practices. DDD has been attributed to the accumulation of environmental factors, primarily mechanical insults and injuries, imposed on the ''normal'' aging changes. However, recent studies have shown an association between genetic influences and disc degeneration, with risk of developing DDD quoted to be increased up to six times that of the general population. It is likely that DDD is a complex, multifactorial disease determined by the interplay between gene(s) and the environment. This review focuses on the evidence for genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition.
- Subjects
INTERVERTEBRAL disk; BACKACHE; GENES; SPINE; CARTILAGE; GENETICS
- Publication
European Spine Journal, 2006, Vol 15, p317
- ISSN
0940-6719
- Publication type
Article
- DOI
10.1007/s00586-006-0171-3