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- Title
Is there association between statin usage and contrast-associated acute kidney injury after intravenous administration of iodine-based contrast media in enhanced computed tomography?
- Authors
Park, Jae Hyon; Shin, Hye Jung; Choi, Jin-Young; Lim, Joon Seok; Park, Mi-Suk; Kim, Myeong-Jin; Oh, Hyung Jung; Chung, Yong Eun
- Abstract
<bold>Objectives: </bold>Contrast-induced acute kidney injury (CI-AKI) is one of the leading causes of new-onset renal failure in hospitalized patients. Statin has been evaluated for its protective effect against CI-AKI but rarely in patients receiving intravenous (IV) administrations of iodine-based contrast media for enhanced computed tomography (CT).<bold>Methods: </bold>In total, 12,371 patients who underwent contrast-enhanced abdominopelvic CT were retrospectively reviewed and stratified into statin users and statin nonusers. Subgroup analyses comparing high-intensity statins with low- to moderate-intensity statins were conducted within statin users and similar comparisons were performed within statin users stratified based on baseline eGFR.<bold>Results: </bold>Overall, CI-AKI events did not occur less in statin users compared with non-statin users (p = 0.342). Within statin users, CI-AKI events did not decrease in high-intensity statin users compared with low- to moderate-intensity statin users (p = 0.355). Moreover, no significant difference in CI-AKI events was found between high-intensity statin users and low- to moderate-intensity statin users even after stratifying the patients with baseline eGFR.<bold>Conclusions: </bold>Collectively, statin was not significantly associated with the risk of CI-AKI events in patients undergoing contrast-enhanced abdominopelvic CT and high-intensity statins did not show significant association with CI-AKI over low- to moderate-intensity statins in the subgroup analysis.<bold>Key Points: </bold>• Statin is not associated with risk of CI-AKI events in patients undergoing intravenous administration of contrast-enhanced CT. • CI-AKI incidence among high-intensity statin users was not significantly different from that of low- to moderate-intensity statin users.
- Subjects
ACUTE kidney failure; CONTRAST media; INTRAVENOUS therapy; COMPUTED tomography; MULTIDETECTOR computed tomography; ANTILIPEMIC agents; COMPARATIVE studies; GLOMERULAR filtration rate; IODINE; RESEARCH methodology; MEDICAL cooperation; KIDNEY failure; RESEARCH; EVALUATION research; RETROSPECTIVE studies
- Publication
European Radiology, 2020, Vol 30, Issue 10, p5261
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-020-06897-4