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- Title
Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells.
- Authors
Il-Kang Na; Keilholz, Ulrich; Letsch, Anne; Bauer, Sandra; Asemissen, Anne; Nagorsen, Dirk; Thiel, Eckhard; Scheibenbogen, Carmen
- Abstract
T-cell trafficking is determined by expression patterns of chemokine receptors. The chemokine receptor CXCR3 is expressed on a subpopulation of type 1 T cells and plays an important role for migration of T cells into inflamed and tumor tissues. Here, we studied the chemokine receptor expression on specific T cells generated against the neoantigen keyhole limpet hemocyanin (KLH) in patients who had been immunized in the context of a tumor peptide vaccination trial with or without the adjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF). In patients immunized in the presence of GM-CSF the fraction of CXCR3+ KLH-specific T cells was significantly higher than in patients immunized in the absence of GM-CSF (median 45 vs. 20%, P = 0.001). In contrast, the chemokine receptor CCR4, associated with migration to the skin was found in both cohorts on less than 10% of KLH-specific T cells. These results show that CXCR3 expression on vaccine-induced T cells can be modulated by modifying the local vaccine milieu.
- Subjects
CHEMOKINES; PEPTIDES; GRANULOCYTE-macrophage colony-stimulating factor; FISSURELLIDAE; VACCINATION; T cells; CELL receptors; HEMOCYANIN
- Publication
Cancer Immunology, Immunotherapy, 2007, Vol 56, Issue 3, p391
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-006-0198-7