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- Title
Coat protein-independent cell-to-cell movement of bromoviruses expressing brome mosaic virus movement protein with an adaptation-related amino acid change in the central region.
- Authors
Sasaki, N.; Kaido, M.; Okuno, T.; Mise, K.
- Abstract
The movement protein (MP) ofBrome mosaic virus(BMV) depends on the coat protein (CP) to mediate the cell-to-cell movement of BMV and CCMV(B3a), a recombinantCowpea chlorotic mottle virus(CCMV) expressing BMV MP. Previous studies identified gain-of-function mutations in the central region of BMV MP that enable CCMV(B3a) to adapt to a resistant host. This study demonstrates that all adaptation-related MPs can partially or almost fully mediate the cell-to-cell movement of CCMV(B3a) and BMV without CP. Based on these results, we discuss adaptation mechanisms of CCMV(B3a) and the role of the central region of MP in the determination of virus movement mode.
- Subjects
VIRUSES; GENETIC vectors; MICROORGANISMS; DNA polymerases; POLYMERASE chain reaction; REVERSE transcriptase
- Publication
Archives of Virology, 2005, Vol 150, Issue 6, p1231
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-004-0481-x