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- Title
Amdinocillin: Interaction with Other Beta-Lactam Antibiotics for Gram-Negative Bacteria.
- Authors
Eng, Robert H.K.; Liu, Rosita; Smith, Sharon M.; Johnson, Edward S.; Cherubin, Charles E.
- Abstract
Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checkerboard double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose. Copyright © 1988 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1988, Vol 34, Issue 1, p18
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238542