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- Title
Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.
- Authors
Billion, Stéphane; Tribout, Bruno; Cadet, Estelle; Queinnec, Colette; Rochette, Jacques; Wheatley, Pascal; Bataille, Pierre
- Abstract
Background. Hyperhomocysteinaemia, a risk factor for atherosclerosis, is common in dialysis patients and particularly in those homozygous for a common polymorphism in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene (C677T transition). B‐complex vitamin supplements have been shown to lower plasma total homocysteine (tHcy) concentrations, but the respective effectiveness of folate and oral vitamin B12 is not yet known. Our objectives were: (i) to determine the status of folate and vitamin B12 in a cohort of unsupplemented dialysis patients (ii) to assess the homocysteine‐lowering effect of a folate supplement and then of a folate supplement with added vitamin B12. The responses were analysed for the C677T genotypes of MTHFR.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 3, p455
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.3.455